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Drug: Tetracycline

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Total 6113 results found since Jan 2013.

Mouse models of vascular development and disease
Purpose of review The use of genetic models has facilitated the study of the origins and mechanisms of vascular disease. Mouse models have been developed to specifically target endothelial cell populations, with the goal of pinpointing when and where causative mutations wreck their devastating effects. Together, these approaches have propelled the development of therapies by providing an in-vivo platform to evaluate diagnoses and treatment options. This review summarizes the most widely used mouse models that have facilitated the study of vascular disease, with a focus on mouse models of vascular malformations and the ...
Source: Current Opinion in Hematology - April 3, 2021 Category: Hematology Tags: VASCULAR BIOLOGY: Edited by M. Luisa Iruela-Arispe Source Type: research

CTCFL expression is associated with cerebral vascular abnormalities
Tissue Cell. 2021 Mar 16;72:101528. doi: 10.1016/j.tice.2021.101528. Online ahead of print.ABSTRACTCTCFL is expressed in testis, oocytes and embryonic stem cells, and is aberrantly expressed in malignant cells, and is classified as a cancer-testis gene. We have previously shown by using a tetracycline-inducible Ctcfl transgene that inappropriate expression of Ctcfl negatively impacts fetal development and causes early postnatal lethality in the mouse. The affected pups displayed severe vascular abnormalities and localized hemorrhages in the brain evocative of cerebral cavernous malformations (CCM) and arteriovenous malform...
Source: Tissue and Cell - March 23, 2021 Category: Cytology Authors: Leyla Sati Bikem Soygur Ethem Goksu Cumhur Ibrahim Bassorgun James McGrath Source Type: research

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
Abstract Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase expression is under the control of a tetracycline (doxycycline, DOX) promoter, were used to assess the contribution of ACE/RAS to microvascular remodeling in 20-HETE-dependent hypertension. Treatment of Cyp4a12tg mice with DOX increased systolic blood pressure (SBP, 136±2 vs. 102±1 mmHg; p<0.05) and this increase was prevented by administration of 20-HEDGE, lisinopril...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 29, 2015 Category: Physiology Authors: Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger KH, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Laniado Schwartzman M Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Abstract A07: Breast tumor microenvironment shapes vascular response to endothelial HoxA5 expression
Current anti-angiogenic therapy for the treatment of solid tumors is based on directed inhibition of growth factor signaling pathways essential for the development of new blood vessels. Despite evidence showing a positive correlation between angiogenesis and breast cancer progression, existing anti-angiogenic therapies have not proven effective at clinically managing breast tumors or prolonging patient survival. Several studies have shown that tissue microenvironment shapes local angiogenic responses and tumor progression - a finding that may partially explain the refractoriness of breast tumors to anti-angiogenic therapy....
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Northcott, J., Cuevas, I., Layman, H., Boudreau, N. Tags: Tumor-Associated Blood Vessels and Lymphatics Source Type: research

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension
Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin-converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase expression is under the control of a tetracycline (doxycycline, DOX) promoter, were used to assess the contribution of ACE/RAS to microvascular remodeling in 20-HETE-dependent hypertension. Treatment of Cyp4a12tg mice with DOX increased systolic blood pressure (SBP; 136 ± 2 vs. 102 ± 1 mmHg; P < 0.05), and this increase was prevented by administration of 20-HEDGE, lisinopri...
Source: AJP: Regulatory, Integrative and Comparative Physiology - July 1, 2015 Category: Physiology Authors: Garcia, V., Joseph, G., Shkolnik, B., Ding, Y., Zhang, F. F., Gotlinger, K., Falck, J. R., Dakarapu, R., Capdevila, J. H., Bernstein, K. E., Schwartzman, M. L. Tags: Hormones, Reproduction and Development Source Type: research

Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury
Conclusions: IR induces a retinal neuroinflammation within hours of reperfusion characterized by inflammatory gene expression, leukocyte adhesion and invasion, and vascular permeability. Despite Mino significantly inhibiting these responses, it failed to block neurodegeneration.
Source: Journal of Neuroinflammation - December 10, 2013 Category: Neurology Authors: Steven AbcouwerCheng-mao LinSumathi ShanmugamArivalagan MuthusamyAlistair BarberDavid Antonetti Source Type: research

Vascular Injury Characterizes Doxycycline-induced Upper Gastrointestinal Tract Mucosal Injury
Doxycycline is an oral tetracycline antibiotic that has been associated with upper gastrointestinal (GI) mucosal injury. Recently, characteristic vascular degeneration has been reported in the stomach and duodenum in patients with doxycycline-induced injury. Fourteen patients who underwent upper GI endoscopy for nonspecific symptoms and were found to have doxycycline-induced gastric and esophageal injury are described. Most patients showed characteristic vascular injury. A control group of gastric erosions and esophageal ulcers showed no cases with the characteristic vascular changes. Clinical, endoscopic, and pathologic f...
Source: The American Journal of Surgical Pathology - February 15, 2017 Category: Pathology Tags: Original Articles Source Type: research

Direct conversion of human fibroblasts into therapeutically active vascular wall-typical mesenchymal stem cells.
Abstract Cell-based therapies using adult stem cells are promising options for the treatment of a number of diseases including autoimmune and cardiovascular disorders. Among these, vascular wall-derived mesenchymal stem cells (VW-MSCs) might be particularly well suited for the protection and curative treatment of vascular damage because of their tissue-specific action. Here we report a novel method for the direct conversion of human skin fibroblasts towards MSCs using a VW-MSC-specific gene code (HOXB7, HOXC6 and HOXC8) that directs cell fate conversion bypassing pluripotency. This direct programming approach usin...
Source: Cellular and Molecular Life Sciences : CMLS - November 10, 2019 Category: Cytology Authors: Steens J, Unger K, Klar L, Neureiter A, Wieber K, Hess J, Jakob HG, Klump H, Klein D Tags: Cell Mol Life Sci Source Type: research

The Efficacy of Systemic Doxycycline Administration as an Inhibitor of Intimal Hyperplasia after Balloon Angioplasty Arterial Injury
Intimal hyperplasia (IH) is the most common indicator for secondary intervention in peripheral vascular disease. Matrix metalloproteinases (MMPs) play a role in IH development due to their degradation of the extracellular matrix. Doxycycline (Doxy), a member of the tetracycline family of antibiotics, is a potent MMP inhibitor. We have previously shown that Doxy inhibits  MMP activity and vascular smooth muscle cell migration in vitro. We hypothesized that Doxy would decrease MMP activity in vivo and inhibit the development of IH in a rodent model of vascular injury.
Source: Annals of Vascular Surgery - January 23, 2019 Category: Surgery Authors: Deidra J.H. Mountain, Stacy S. Kirkpatrick, Joshua D. Arnold, M. Ryan Buckley, Michael M. McNally, Scott L. Stevens, Michael B. Freeman, Oscar H. Grandas Tags: Clinical Research Source Type: research

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium
Conclusion The findings suggest that NOX-derived ROS results in increased mito-ROS. Whereas short-term increase in mito-ROS was counteracted by MnSOD, long-term increase in ROS resulted in nitrotyrosine-mediated inactivation of MnSOD, leading to unchecked increase in mito-ROS and loss of m followed by inhibition of endothelial function and proliferation.
Source: Cardiovascular Research - January 22, 2017 Category: Cardiology Authors: Shafique, E., Torina, A., Reichert, K., Colantuono, B., Nur, N., Zeeshan, K., Ravichandran, V., Liu, Y., Feng, J., Zeeshan, K., Benjamin, L. E., Irani, K., Harrington, E. O., Sellke, F. W., Abid, M. R. Tags: Vascular biology Source Type: research